Which finitely generated Abelian groups admit isomorphic Cayley graphs?

We show that Cayley graphs of finitely generated Abelian groups are rather rigid. As a consequence we obtain that two finitely generated Abelian groups admit isomorphic Cayley graphs if and only if they have the same rank and their torsion parts have the same cardinality. The proof uses only elementary arguments and is formulated in a geometric language.Comment: 16 pages; v2: added reference, reformulated quasi-convexity, v3: small corrections; to appear in Geometriae Dedicat

On Anomaly-Free Dark Matter Models

We investigate the predictions of anomaly-free dark matter models for direct and indirect detection experiments. We focus on gauge theories where the existence of a fermionic dark matter candidate is predicted by anomaly cancellation, its mass is defined by the new symmetry breaking scale, and its stability is guaranteed by a remnant symmetry after the breaking of the gauge symmetry. We find an upper bound on the symmetry breaking scale by applying the relic density and perturbative constraints. The anomaly-free property of the theories allows us to perform a full study of the gamma lines from dark matter annihilation. We investigate the correlation between predictions for final radiation processes and gamma lines. Furthermore, we demonstrate that the latter can be distinguished from the continuum gamma ray spectrum.Comment: 21 pages, 9 figures. v2: minor changes to the text, references added, version to appear in PR

A novel epigenetic AML1-ETO/THAP10/miR-383 mini-circuitry contributes to t(8;21) leukaemogenesis

DNA methylation patterns are frequently deregulated in t(8;21) acute myeloid leukaemia (AML), but little is known of the mechanisms by which specific gene sets become aberrantly methylated. Here, we found that the promoter DNA methylation signature of t(8;21)(+) AML blasts differs from that of t(8;21)(-) AMLs. This study demonstrated that a novel hypermethylated zinc finger-containing protein, THAP10, is a target gene and can be epigenetically suppressed by AML1-ETO at the transcriptional level in t(8;21) AML. Our findings also show that THAP10 is a bona fide target of miR-383 that can be epigenetically activated by the AML1-ETO recruiting co-activator p300. In this study, we demonstrated that epigenetic suppression of THAP10 is the mechanistic link between AML1-ETO fusion proteins and tyrosine kinase cascades. In addition, we showed that THAP10 is a nuclear protein that inhibits myeloid proliferation and promotes differentiation both in vitro and in vivo Altogether, our results revealed an unexpected and important epigenetic mini-circuit of AML1-ETO/THAP10/miR-383 in t(8;21) AML, in which epigenetic suppression of THAP10 predicts a poor clinical outcome and represents a novel therapeutic target

Phase II prospective randomized trial of weight loss prior to radical prostatectomy.

BACKGROUND:Obesity is associated with poorly differentiated and advanced prostate cancer and increased mortality. In preclinical models, caloric restriction delays prostate cancer progression and prolongs survival. We sought to determine if weight loss (WL) in men with prostate cancer prior to radical prostatectomy affects tumor apoptosis and proliferation, and if WL effects other metabolic biomarkers. METHODS:In this Phase II prospective trial, overweight and obese men scheduled for radical prostatectomy were randomized to a 5-8 week WL program consisting of standard structured energy-restricted meal plans (1200-1500 Kcal/day) and physical activity or to a control group. The primary endpoint was apoptotic index in the radical prostatectomy malignant epithelium. Secondary endpoints were proliferation (Ki67) in the radical prostatectomy tissue, body weight, body mass index (BMI), waist to hip ratio, body composition, and serum PSA, insulin, triglyceride, cholesterol, testosterone, estradiol, leptin, adiponectin, interleukin 6, interleukin 8, insulin-like growth factor 1, and IGF binding protein 1. RESULTS:In total 23 patients were randomized to the WL intervention and 21 patients to the control group. Subjects in the intervention group had significantly more weight loss (WL:-3.7 ± 0.5 kg; Control:-1.6 ± 0.5 kg; p = 0.007) than the control group and total fat mass was significantly reduced (WL:-2.1 ± 0.4; Control: 0.1 ± 0.3; p = 0.015). There was no significant difference in apoptotic or proliferation index between the groups. Among the other biomarkers, triglyceride, and insulin levels were significantly decreased in the WL compared with the control group. CONCLUSIONS:In summary, this short-term WL program prior to radical prostatectomy resulted in significantly more WL in the intervention vs. the control group and was accompanied by significant reductions in body fat mass, circulating triglycerides, and insulin. However, no significant changes were observed in malignant epithelium apoptosis or proliferation. Future studies should consider a longer term or more intensive weight loss intervention

Creep stability of the proposed AIDA mission target 65803 Didymos: I. Discrete cohesionless granular physics model

As the target of the proposed Asteroid Impact & Deflection Assessment (AIDA) mission, the near-Earth binary asteroid 65803 Didymos represents a special class of binary asteroids, those whose primaries are at risk of rotational disruption. To gain a better understanding of these binary systems and to support the AIDA mission, this paper investigates the creep stability of the Didymos primary by representing it as a cohesionless self-gravitating granular aggregate subject to rotational acceleration. To achieve this goal, a soft-sphere discrete element model (SSDEM) capable of simulating granular systems in quasi-static states is implemented and a quasi-static spin-up procedure is carried out. We devise three critical spin limits for the simulated aggregates to indicate their critical states triggered by reshaping and surface shedding, internal structural deformation, and shear failure, respectively. The failure condition and mode, and shear strength of an aggregate can all be inferred from the three critical spin limits. The effects of arrangement and size distribution of constituent particles, bulk density, spin-up path, and interparticle friction are numerically explored. The results show that the shear strength of a spinning self-gravitating aggregate depends strongly on both its internal configuration and material parameters, while its failure mode and mechanism are mainly affected by its internal configuration. Additionally, this study provides some constraints on the possible physical properties of the Didymos primary based on observational data and proposes a plausible formation mechanism for this binary system. With a bulk density consistent with observational uncertainty and close to the maximum density allowed for the asteroid, the Didymos primary in certain configurations can remain geo-statically stable without including cohesion.Comment: 66 pages, 24 figures, submitted to Icarus on 25/Aug/201

Parallel driving in CPSS: a unified approach for transport automation and vehicle intelligence

The emerging development of connected and automated vehicles imposes a significant challenge on current vehicle control and transportation systems. This paper proposes a novel unified approach, Parallel Driving, a cloud-based cyberphysical-social systems U+0028 CPSS U+0029 framework aiming at synergizing connected automated driving. This study first introduces the CPSS and ACP-based intelligent machine systems. Then the parallel driving is proposed in the cyber-physical-social space, considering interactions among vehicles, human drivers, and information. Within the framework, parallel testing, parallel learning and parallel reinforcement learning are developed and concisely reviewed. Development on intelligent horizon U+0028 iHorizon U+0028 and its applications are also presented towards parallel horizon. The proposed parallel driving offers an ample solution for achieving a smooth, safe and efficient cooperation among connected automated vehicles with different levels of automation in future road transportation systems

Leptophobic Dark Matter and the Baryon Number Violation Scale

We discuss the possible connection between the scale for baryon number violation and the cosmological bound on the dark matter relic density. A simple gauge theory for baryon number which predicts the existence of a leptophobic cold dark matter particle candidate is investigated. In this context, the dark matter candidate is a Dirac fermion with mass defined by the new symmetry breaking scale. Using the cosmological bounds on the dark matter relic density we find the upper bound on the symmetry breaking scale around 200 TeV. The properties of the leptophobic dark matter candidate are investigated in great detail and we show the prospects to test this theory at current and future experiments. We discuss the main implications for the mechanisms to explain the matter and antimatter asymmetry in the Universe

Corpora and evaluation tools for multilingual named entity grammar development

We present an effort for the development of multilingual named entity grammars in a unification-based finite-state formalism (SProUT). Following an extended version of the MUC7 standard, we have developed Named Entity Recognition grammars for German, Chinese, Japanese, French, Spanish, English, and Czech. The grammars recognize person names, organizations, geographical locations, currency, time and date expressions. Subgrammars and gazetteers are shared as much as possible for the grammars of the different languages. Multilingual corpora from the business domain are used for grammar development and evaluation. The annotation format (named entity and other linguistic information) is described. We present an evaluation tool which provides detailed statistics and diagnostics, allows for partial matching of annotations, and supports user-defined mappings between different annotation and grammar output formats

Formation Criteria of High Efficiency Perovskite Solar Cells in Ambient Conditions

The field of lead halide perovskites for solar cell applications has recently reported impressive power conversion (PCE) above 22 % using complex mixed cation formulations. Very importantly, highest PCE have been obtained using totally dry environmental conditions increasing the processing costs (i.e. use of glovebox). In this work devices processed in air under different ambient conditions are prepared with PCE approaching 19 % for the simplest lead halide perovskite (MAPbI3, MA= Methyl ammonium). It is shown that the PbI2:MAI:additive complex needs to be generated in the correct stoichiometry (1:1:1) where additives are any highly polar molecule able to stabilize the complex (i.e. H2O or Dimethylsulphoxide (DMSO)). At high humidity conditions H2O is incorporated into the complex and only small concentrations of further additives are needed. Precursor formulations not adequately balanced for the humidity conditions lead to films with poor morphology as evidenced by SEM. These films show negative multiiodide plumbate chemical defects as observed by absorbance measurements. These chemical defects act as recombination centers reducing the photocurrent and Fill Factor in photovoltaic devices. In addition, it is shown the undesirable high conductivity of the perovskite hydrates (8x10-1 Scm-1), up to seven orders of magnitude higher than the pure MAPbI3, indicating that the presence of hydrates may act as shunting pathways that can significantly reduce the open circuit potential